Is Alzheimer’s a Form of Diabetes?
Last month I got a little personal. This month I am taking you to the very cutting edge of scientific thought. There seems to be a real connection between diabetes and dementia. Someone coined the term that Diabetes Type 3.
Type 3 diabetes appears to be abnormal insulin effects in the brain resulting in histochemical and pathological changes identical to those found in Alzheimer’s brains.
Until recently I had never heard this term. The contention is that Alzheimer’s Disease is really a brain form of diabetes. This is not really new info in the scientific community but it sure didn’t make it to the front line caregivers. The real culprit, as I understand it, is once again INSULIN. Simplistically Type 1 diabetics have no insulin and need to take shots of insulin to control their blood sugar. Insulin is a growth hormone that pushes the sugar in your bloodstream into the individual cells where they can be used. Type 2 diabetics don’t respond as well or strongly to the high sugar in your blood so it takes more insulin than normal to get the sugars into cells. This is called insulin resistance. Type 3 diabetes appears to be abnormal insulin effects in the brain resulting in histochemical and pathological changes identical to those found in Alzheimer’s brains. This is big big news which appears to be based on pretty good scientific underpinnings. The idea that Alzheimer’s is a form of diabetes has been around since 2005. Roughly one third of Americans have diabetes. Diabetes and dementia are both epidemic in this country and increasing over time. It has been known for some time that diabetic patients are 2-4 times as likely to become demented as those who are not diabetic. Besides telling the bodies cells to take in sugar, Insulin also tells fat cells to grow. If you are Insulin resistant, which the vast majority of Type 2 diabetics are , you have higher amounts of insulin in your bloodstream to keep your sugars under control. This same higher insulin level makes losing weight very difficult because insulin puts your body in growth mode not weight loss mode. You need insulin to live but you want to get away with as little as possible.
Suzanne de la Monte a neuropathologist at Brown University did rat research that showed when she blocked insulin to the rats brains they acted demented and their brains showed “all the signs of Alzheimer’s”.
Alzheimer’s is no longer just a “condition that befalls us by chance.” You might be able to dramatically decrease your risk of dementia with your diet and exercise program. No fancy medications, no special treatments.
Shall we get more technical? In the Journal of Diabetes Science and Technology published November 2008 experts reviewed the evidence regarding this possible connection and found “extensive disturbances in brain insulin and insulin like growth factor (IGF) signaling mechanisms represent early and progressive abnormalities and could account for the majority of molecular, biochemical, and histopathological lesions found in Alzheimer’s Disease. “ Furthermore , when they experimentally induced brain diabetes these rats brains shared many features with Alzheimer’s and when they treated these rats with currently used insulin sensitizers the changes were reversible. Now we are not rats and many times what’s true in rats and mice does not translate to humans but it’s a pretty strong chain of evidence nonetheless.
Shall we talk numbers? According to an article in the NY Times…Diabetes and Dementia have nearly tripled in the US in the last 40 years. Both Diabetes and Dementia are separately listed among the top ten causes of death in America today. Currently 2 % of Americans have dementia…that’s over 5 million people and dementia costs our healthcare system 200 billion dollars. Add the cost of Dementia care and the cost of Diabetic care and you are talking some real money and a real impact on the health care system.
For further reading check out the well known Dr. David Perlmutter’s book Grain Brain.
The most important finding in all this is that Alzheimer’s is no longer just a “condition that befalls us by chance.” You might be able to dramatically decrease your risk of dementia with your diet and exercise program. No fancy medications, no special treatments. The same diet that can improve your brain is the very same diet that improves your heart, your waistline, and your liver….so now what’s stopping you ! Next month we finally take on the supplement industry with hard science and new technology. Stay tuned…until next month…get well and stay well. Jtb
